Top 4 Medications for Managing Depression Symptoms
Discover four leading medications used to treat depression, including Zoloft, Prozac, Trazodone, and Wellbutrin XL. These drugs are essential in managing symptoms of depression, anxiety, and related disorders, offering significant discounts through GoodRx Gold. Learn about their uses, benefits, and savings options for effective mental health management.

Depression is a complex mental health condition characterized by prolonged periods of sadness, loss of interest, and behavioral changes. It can lead to physical issues like fatigue and mental health challenges such as hopelessness and irritability. Overcoming depression requires comprehensive treatment, including medication, therapy, and lifestyle adjustments. Medications play a vital role, often including antidepressants, anti-anxiety, or antipsychotic drugs. Here are four commonly prescribed medications to help alleviate depressive symptoms:
Zoloft (Sertraline)
Sertraline, marketed as Zoloft, is a widely used SSRI that enhances serotonin levels in the brain, helping improve mood. It's prescribed for depression, panic disorder, anxiety, PMDD, OCD, and PTSD. Patients can access significant savings through GoodRx Gold, with up to 88% off on 30 tablets of 50 mg sertraline and up to 17% off for branded Zoloft.
Prozac (Fluoxetine)
Fluoxetine, known as Prozac, is another SSRI effective for major depression, eating disorders, and anxiety. It influences brain neurotransmitters to ease symptoms like panic and OCD. Both generic and branded options are available, with GoodRx Gold offering up to 86% savings on 30 capsules of 20 mg fluoxetine, and up to 21% discount on brand-name Prozac.
Trazodone
Trazodone, a cost-effective generic medication, is primarily used to treat depression, improve appetite and energy, and reduce insomnia linked to depression. GoodRx Gold can provide discounts of up to 83% on 30 tablets of 50 mg trazodone, with prices varying based on dosage and pharmacy.
Wellbutrin XL (Bupropion XL)
Bupropion XL, branded as Wellbutrin XL, is particularly effective for major depression and seasonal affective disorder management. GoodRx offers substantial discounts, up to 87% on 30 tablets of 300 mg, while other options may save up to 10%.
GoodRx Gold memberships unlock significant savings at major pharmacies nationwide, including CVS, Target, Kroger, and Safeway.