Top 5 Preventive Medications for Protecting Dogs from Heartworm
Discover the top five effective medications for preventing heartworm in dogs. This article reviews popular options like Simparica Trio, Heartgard Plus, Tri-Heart Plus, Iverhart Plus, and Proheart. Learn about their usage, benefits, and safety for protecting your furry friend from life-threatening heartworm disease through easy, veterinarian-approved treatments tailored for dogs of all ages and breeds.

Heartworm disease, caused by a parasitic worm transmitted through mosquitoes, poses a serious threat to dogs. Once infected, worms travel to the dog’s lungs and heart, leading to severe health issues that often require intensive treatment and extended recovery periods. Preventing infection is crucial for dog owners. Several medications are effective in safeguarding pets from heartworm and related parasites. Here are five widely recommended options:
Simparica Trio®—A popular chewable tablet that prevents heartworm infections, along with treating stomach worms, hookworms, and roundworms. It’s safe for puppies starting at eight weeks old.
Heartgard Plus—An oral medication with a tasty beef flavor, containing ivermectin and pyrantel pamoate. It protects against heartworms, hookworms, and roundworms.
Tri-Heart® Plus—A cost-effective alternative to other medications, suitable for all dog breeds, preventing heartworms and intestinal worms such as roundworms, hookworms, and whipworms.
Iverhart Plus—A flavored chewable tablet effective against heartworms, hookworms, and roundworms, typically administered monthly after veterinary consultation.
Proheart—An injectable preventative used when monthly tablets aren’t feasible. Contains moxidectin to protect against heartworms and hookworms, administered under veterinary supervision due to potential side effects.