Understanding Peyronie's Disease: Causes, Symptoms, and Treatments
This comprehensive overview explores Peyronie's disease, its causes, symptoms, and treatment options. It highlights lifestyle changes, medical therapies like injections and shockwave therapy, and surgical procedures for severe cases, emphasizing the importance of early diagnosis and professional consultation for effective management.

Peyronie's disease is a condition affecting men, characterized by the development of fibrous scar tissue inside the penis. This tissue, known as plaque, often results from injury, internal bleeding, or other factors like vitamin deficiencies, elevated serotonin levels, or medication side effects. The condition causes the penis to bend, usually during an erection, leading to discomfort and difficulty during intercourse.
This disease primarily affects middle-aged men and can occur in approximately 1% to 8% of men.
Key Symptoms include:
Pain during erection and sex
Penile curvature
Soft erections
Penile shortening
Difficulty maintaining intercourse
Stress and anxiety
To reduce risk, lifestyle modifications such as quitting smoking, exercising regularly, limiting alcohol, and avoiding non-prescribed medications are recommended.
Treatment varies based on severity. Sometimes, if symptoms are mild and erectile function remains normal, doctors may suggest observing the condition. If persistent, options include injections like collagenase, which breaks down scar tissue, and medications such as verapamil and interferon that hinder collagen formation and reduce pain.
Shockwave therapy utilizing high-energy sound waves can target calcified plaques, helping to improve symptoms. Surgery is considered for severe cases unresponsive to conservative methods, involving tissue removal, grafting, or implantation of devices to straighten the penis. Medications in early stages include vitamin E, tamoxifen, colchicine, and others. Consulting a healthcare professional promptly is essential for effective management.