Top Mississippi River Cruise Experiences You Can Enjoy
Experience the best of the Mississippi River with top cruise options like Twilight Riverboat, American Queen, Spirit of Peoria, and American Cruise Lines. These cruises range from quick day trips to extensive 22-day journeys, offering luxurious accommodations, scenic views, cultural insights, and port explorations across historic cities. Perfect for those seeking relaxation, adventure, and a taste of America's river heritage.

Discover the Best Mississippi River Cruises
Embark on a relaxing journey along the mighty Mississippi River to escape daily stress. Several reputable cruise lines offer unforgettable river adventures, showcasing the scenic beauty and historic charm of this iconic waterway. Here are some top Mississippi River cruise options to consider for your next getaway.
Twilight Riverboat
For a quick escape, the Twilight Riverboat provides elegant day trips and overnight voyages. Departing from Dubuque, the cruise heads north to Guttenberg and returns by evening, offering breakfast, lunch, and snacks. The two-day trips from Le Claire allow exploration of Dubuque’s museums, markets, and architecture while learning about local history and landscapes.
American Queen
Known for blending vintage charm with modern amenities, the American Queen offers luxurious staterooms, gourmet dining, and lively entertainment. Guests can indulge in spa services, attend cultural talks, and explore historic river cities. Cruises range from 5 to 9 days, visiting ports such as Baton Rouge, Memphis, Natchez, Vicksburg, and St. Louis.
Spirit of Peoria
The Spirit of Peoria specializes in overnight trips lasting 2 to 5 days, perfect for a week-long vacation. Popular routes include St. Louis, Starved Rock, and Hannibal, featuring meals, live entertainment, storytelling, and port excursions. The cruise line offers themed, sightseeing, and private charter options for a tailored experience.
American Cruise Lines
For extended exploration, the Mississippi River cruise by American Cruise Lines covers 10 states in 22 days. Starting in New Orleans and ending in St. Paul, this voyage offers a diverse array of cityscapes, history, and culture, providing an immersive American journey across its historic heartland.