Effective Strategies for Managing Psoriasis Symptoms

Psoriasis is a persistent autoimmune skin disorder characterized by rapid skin cell growth, leading to inflammation and scaling. If left untreated, it may lead to complications like psoriatic arthritis, heart issues, and metabolic diseases. Fortunately, various treatment options can help control the condition.

Common therapies include methotrexate, oral retinoids, and ciclosporin, which alleviate symptoms but do not cure the disease. The choice of treatment depends on factors like age, overall health, severity, and affected areas.

Advancements in immunology have led to the development of new drugs that outperform traditional options.

Anti-TNF Therapy

Patients with psoriasis often exhibit elevated levels of tumor necrosis factor alpha (TNF-α), which promotes inflammation. Anti-TNF agents bind to TNF-α, preventing it from triggering cytokine production, thereby reducing immune cell activation.

Currently, three main TNF-α inhibitors are used: Etanercept, a fusion protein capturing soluble TNF-α; Adalimumab, a monoclonal antibody targeting TNF-α; and Certolizumab pegol, used in phase II trials. These treatments can significantly decrease inflammation with bi-weekly doses.

T-Cell Modulation

Alefacept, a fusion protein, inhibits T-cell activation and proliferation, curbing inflammation caused by psoriasis.

Light Therapy

Phototherapy, involving controlled ultraviolet light exposure, effectively manages psoriasis symptoms. It is more reliable and safer than indoor tanning, which increases skin cancer risk. Home UVB units are a cost-effective option, but insurance coverage should be checked beforehand. PUVA therapy (Psoralen + UVA) is also effective, especially for stubborn plaques and palmoplantar psoriasis.

Nerve Growth Factor Blockade

Stress releases neuropeptides that affect keratinocyte growth. CT327, a topical NGF receptor blocker, reduces nerve-related inflammation, offering another treatment avenue.

Herbal Approaches

Consult your healthcare provider before trying herbal remedies to avoid adverse interactions, especially if you have pre-existing conditions like hypertension, diabetes, or mood disorders. Some natural options include:

Apple Cider Vinegar - Diluted apple cider vinegar can alleviate scalp itching. Apply it on the scalp for a week, avoiding cracked or bleeding skin.

Aloe Vera Gel - Applying pure aloe vera thrice daily reduces redness and scaling. Avoid aloe tablets, as they can be harmful.

Dead Sea Salts - Adding salts to bathwater soothes itching and softens scales. Use moisturizer afterward for best results.

Capsaicin - This component in chili peppers can block nerve signals and reduce psoriasis symptoms when used in creams. Some may experience a burning sensation, so consult a doctor if discomfort persists.

Tea Tree Oil - Known for its antiseptic properties, it can help with scalp psoriasis, but allergy risk suggests a patch test first.