Uncovering Hidden Triggers of Migraines
Discover hidden migraine triggers including tyramine-rich foods, medication side effects, hormone therapy, and nitrates. Understanding these factors can help manage and prevent migraine episodes effectively. Consult your doctor for personalized advice to reduce headache frequency and intensity. Recognize the connection between diet, medication, and migraines to improve your quality of life.

Several foods and beverages can unknowingly set off migraines in sensitive individuals, mainly due to certain natural compounds they contain. One key culprit is tyramine, a substance found in fermented or aged foods such as:
Smoked fish
Certain beers
Cured meats
Vintage cheeses
Other protein-rich foods can also contain tyramine if stored improperly or kept at room temperature for too long.
Understanding the link between tyramine and migraines
Research dating back to the 1950s indicates that tyramine can trigger migraine episodes. The chemical structure makes it a monoamine, which the enzyme monoamine oxidase (MAO) breaks down. Drugs inhibiting MAO, like certain antidepressants, can lead to elevated tyramine levels, causing headaches and increased blood pressure. Individuals on such medication should limit tyramine-rich foods.
Foods high in tyramine include:
Aged liver
Red wine
Sauerkraut
Soy sauce
Air-dried or fermented meats
Aged cheeses
Draft beer
Miso soup
Fish sauces
Yeast extract
Some medications, notably certain heart drugs, birth control, and painkillers, can also cause headaches. Adjusting dosages or switching medications can help prevent rebound headaches — recurring pains caused by overuse of pain relief drugs like aspirin, ibuprofen, or migraine-specific medications like triptans.
Hormone therapy for menopause symptoms may also induce headaches. Options such as lower doses or alternative forms like bioidentical estrogen patches can minimize this risk.
For heart patients, nitrates like nitroglycerin often bring relief from chest pain but can cause moderate to severe headaches shortly after intake. Consulting a healthcare professional before making changes or stopping medications is essential.